三.金必蓮教授簡介:
金必蓮，博士，大連醫(yī)科大學腫瘤干細胞研究院教授（博士生導師）。2002年至2012年，先后在佛羅里達大學及佐治亞州健康科學大學從事腫瘤的表觀遺傳學機制研究，并在國際權(quán)威雜志Human Mol Genet, Cancer Research以及Cell的子刊Cell Reports上發(fā)表論文多篇，合著的Epigenetic Alterations in Oncogenesis一書也已出版。于2012年10月底全職回國。近年來在lncRNA和表觀遺傳學的研究已經(jīng)達到國際尖端水平，在Cell Reports，Genes Cancer，Leukemia，Agents Med Chem，Tumor Biology，Oncotarget等國際一流學術(shù)期刊發(fā)表多篇學術(shù)論文。
代表文章：
(1) J Lou; Y Hao; K Lin; Y Lyu; M Chen; H Wang; D Zou; X Jiang; R Wang; D Jin;EW-F Lam; S Shao; Q Liu; J Yan; X Wang; P Chen; X Wang; B Zhang; B Jin. Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis. Molecular Cancer, 2020, 19 (1):138.
(2) Y Lyu#; J Lou#; Y Yang#; J Feng#; Y Hao; S Huang; L Yin; J Xu; D Huang; B Ma; D Zou; Y Wang; Y Zhang; B Zhang; P Chen; K Yu; EW-F Lam; X Wang*; Q Liu*; J Yan*; B Jin*. Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways, Leukemia, 2017.12, 31 (12): 2543-2551.
(3) D Lyu; X Wang*; J Dong; Y Zhuang; S Huang; B Ma; P Chen; X Li; B Zhang; Z Li*; B Jin*. Systematic characterization of lncRNAs' cell-to-cell expression heterogeneity in glioblastoma cells, Oncotarget, 2016, 7(14): 18403-18414.
(4) B Jin; J Ernst; R Tiedemann; H Xu; S Sureshchandra; M Kellis; S Dalton; C Liu; J Choi*; K Robertson*. Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells, Cell Report, 2012, 2(5): 1411-1424.
(5) B Jin; B Yao; J Li; C Fields; A Delmas; C Liu; K Robertson*. DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer, Cancer Research, 2009, 69(18): 7412-7421.
(6) B Jin; Q Tao; J Peng; H Soo; W Wu; J Ying; C Fields; A Delmas; X Liu; J Qiu; K Robertson*. DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modications and aberrant expression of genes regulating development, neurogenesis and immune function, Human Molecular Genetics, 2007, 17(5): 690-709.
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